Multiple compartment syringe

ABSTRACT

Various syringe systems are disclosed. One illustrative syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to house a plurality of fluids therein. A first plunger may be positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a U.S. national stage filing under 35 U.S.C. §371 of International Application No. PCT/US2014/024265, filed Mar. 12, 2014, which claims the benefit of U.S. application Ser. No. 13/802,372, filed Mar. 13, 2013 and entitled “Multiple Compartment Syringe,” and which is incorporated herein in its entirety.

BACKGROUND

During a radiological procedure, a contrast medium may be administered to provide improved imaging of anatomical features in a patient. A physician may typically order a specific amount of contrast medium deemed necessary to view these anatomical features. Since the contrast medium may be expensive, it may be important to make sure that the complete dose is administered and that little or no waste is generated. In addition, the contrast medium may need to be pushed to a region of interest or diluted to avoid too much contrast in a region of interest.

Previous attempts to ensure complete contrast medium administration, pushing to a region of interest, and/or dilution involved injecting a flushing material, such as saline solution and/or the like, immediately after the contrast medium in order to flush the administration tube of all residual contrast medium, push the contrast to a region of interest, or dilute the contrast. In some radiological procedures, this may be completed by means of an automated device. However, in some radiological procedures, a manual device may be used for various reasons, such as, for example, an automated device is not available or the procedure does not require the level of delivery control that can be afforded by an automated device. However, the manual devices currently used in the art lack an ability to control delivery in a manner similar to an automated device, thus leading to waste of contrast medium, improperly delivered contrast medium, and/or improperly diluted contrast medium.

Furthermore, it may be necessary to assure that the access vein of the patient remains open when the contrast medium is not actively being delivered. For some patients with diseased vasculature, the vein may collapse when not being actively supplied by contrast medium. In such a condition, some amount of fluid, such as saline solution and/or the like, may be delivered to the vein to keep the vein open (“KVO”).

SUMMARY

In an embodiment, a syringe may include a syringe body having a hollow lumen and a distal end, and the syringe body may be configured to house a plurality of fluids therein. A first plunger may be positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body. In specific embodiments a fluid bypass may be disposed about the inner wall of the syringe body and the first plunger at or near the distal end of the syringe body, wherein a first fluid can flow through the fluid bypass to the second compartment. The syringe may further comprise a mechanism for proximally moving the first plunger to a position proximal to the fluid bypass such that the first plunger forms the first seal. The mechanism may comprise a variety of mechanism such as one of a slidable end cap at the distal end of the syringe body, a push rod configured to push the first plunger in the proximal direction, and a sleeve comprising at least one magnet at or near the distal end of the sleeve and in magnetic communication with at least one magnet or ferromagnetic material in the first plunger.

In an embodiment, a syringe system may include a syringe body having a hollow lumen and a distal end comprising a syringe tip, and the syringe body may be configured to house a plurality of fluids therein. Additionally, a first plunger may be positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. A transfer tube may be in fluid connection with the second compartment and the syringe tip.

In an embodiment, a syringe system may include a syringe body having a hollow lumen and a distal end having a syringe tip. The syringe body may be configured to house a plurality of fluids therein. The syringe system may also include a first plunger positioned in the hollow lumen of the syringe body. The first plunger may form a first seal with an inner wall of the syringe body, and may form a first compartment between the first plunger and the distal end of the syringe. A second plunger may be positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger. The syringe system may also include a transfer tube in fluid connection with the second compartment. The transfer tube may include a valve having an outlet, where the valve is in fluid communication with the syringe tip. The syringe system may also include an outlet port fluidly connected to an outlet of the valve. An orientation of the valve may include one of a first opening state to allow fluid flow from the syringe tip to the outlet port, a second opening state to allow fluid flow from the transfer tube to the outlet port, a third opening state to allow fluid flow from both the syringe tip and the transfer tube to the outlet port, and a closed state to block flow of fluid from the syringe tip and the transfer tube.

In an embodiment, a syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to house a plurality of fluids therein. The syringe system may also include a first plunger positioned in the hollow lumen of the syringe body, forming a first seal within an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe, the first plunger comprising a hollow lumen therein. A second plunger may be positioned in the hollow lumen of the first plunger, forming a second seal within an inner wall of the first plunger, and forming a second compartment between the first plunger and the second plunger.

In an embodiment, a syringe system may include a syringe body having a first chamber, a second chamber, and an outlet fluidly connected to the first chamber and the second chamber. The first chamber may be positioned adjacent to the second chamber. The first chamber may have a diameter that is smaller than a diameter of the second chamber. The first chamber may be configured to house a first fluid and the second chamber may be configured to house a second fluid. The syringe system may also include a first plunger positioned in the first chamber and a second plunger positioned in the second chamber. The syringe system may also include an adjustable stop that is configured to stop distal movement of the first plunger after the first plunger has traversed a defined distance. The second plunger may be configured to move in a distal direction to push the second fluid out of the second chamber into an outlet. The first fluid may be drawn out of the first plunger via a Venturi effect upon distal movement of the second plunger.

BRIEF DESCRIPTION OF THE DRAWINGS

In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized and other changes may be made, without departing from the spirit or scope of the subject matter presented herein. It will be readily understood that the aspects of the present disclosure, as generally described herein and illustrated in the figures, can be arranged, substituted, combined, separated, and designed in a wide variety of different configurations, all of which are explicitly contemplated herein

FIGS. 1A-1B depict a side view of a syringe according to an embodiment.

FIG. 2A depicts a side view of an alternative syringe having a transfer tube according to an embodiment.

FIG. 2B depicts a side view of the alternative syringe of FIG. 2A with an alternatively positioned transfer tube according to an embodiment.

FIG. 3 depicts various alternative orientations of a valve used in the syringe of FIGS. 2A and 2B according to an embodiment.

FIG. 4 depicts a side view of another alternative syringe according to an embodiment.

FIG. 5 depicts a side view of yet another alternative syringe according to an embodiment.

FIGS. 6A-6D depict movement of the various components of the syringe depicted in FIGS. 1A and 1B according to an embodiment.

FIGS. 7A-7C depict movement of the various components of the syringe depicted in FIG. 2A according to an embodiment.

FIGS. 8A-8C depict movement of the various components of the syringe depicted in FIG. 5 according to an embodiment.

FIGS. 9A-9C depict movement of various components of a syringe according to an embodiment

FIGS. 10A and 10B depict an aspiration process of a syringe according to an embodiment.

FIGS. 11A and 11B depict an aspiration process of a syringe according to an embodiment.

DETAILED DESCRIPTION

This disclosure is not limited to the particular systems, devices and methods described, as these may vary. The terminology used in the description is for the purpose of describing the particular versions or embodiments only, and is not intended to limit the scope.

As used in this document, the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. Nothing in this disclosure is to be construed as an admission that the embodiments described in this disclosure are not entitled to antedate such disclosure by virtue of prior invention. As used in this document, the term “comprising” means “including, but not limited to.”

For purposes of the description hereinafter, the terms “upper,” “lower,” “right,” “left,” “vertical,” “horizontal,” “top,” “bottom,” “lateral,” “longitudinal,” and derivatives thereof shall relate to the orientation of embodiments disclosed in the figures. However, embodiments may assume alternative variations and step sequences, except where expressly specified to the contrary. The specific devices and processes illustrated in the attached drawings and described in the following specification, are exemplary embodiments. Hence, physical characteristics related to the embodiments disclosed herein are not to be considered as limiting.

The word “proximal” refers to a direction relatively closer to a clinician or operator using the device described herein, and the word “distal” refers to a direction relatively further from the clinician or operator. For example, the end of a syringe placed nearest the body of a patient is considered a distal end of the syringe, while the end closes to the clinician is a proximal end of the syringe. The terms “axial” or “axially” refer generally to an axis around which the particular objects being referred to are preferably formed (although not necessarily symmetrically therearound). The term “radial” refers generally to a direction normal to the axis or along a radius of an object having a circular cross-section.

Various embodiments of the present disclosure may be directed to devices and methods of use thereof that use a manual device to deliver a bolus of contrast medium followed by an amount of saline solution. In various embodiments, this may serve to flush the line to ensure all of the contrast is delivered to the patient, to move the contrast to a region of interest, and/or to dilute the contrast concentration. In various embodiments, the devices and methods of use may further be capable of delivering a small amount of fluid to maintain vein patency during contrast medium administration.

FIG. 1A depicts a side view of a syringe, generally designated 100, according to an embodiment. The syringe 100 may generally include a syringe body 105 having a hollow lumen 107, a proximal end 101, and a distal end 102 having a tip 110. The syringe body 105 is not limited in shape or size by this disclosure, and may be any shape or size, particularly shapes and sizes of syringe bodies commonly known by those skilled in the art. In various embodiments, the syringe body 105 may substantially cylindrical. In various embodiments where the syringe 100 is configured for use in computed tomography (CT) applications and the like, the syringe body 105 may be configured to contain about 20 ml to about 150 ml of fluid therein. In particular embodiments, the syringe body may be configured to contain about 20 ml, about 25 ml, about 30 ml, about 50 ml, about 75 ml, about 100 ml, about 125 ml, about 150 ml, or any value or range between any two of these values. In various embodiments where the syringe 100 is configured for use in magnetic resonance (MR) applications and the like, the syringe body 105 may be configured to contain about 5 ml to about 20 ml of fluid therein. In particular embodiments, the syringe body may be configured to contain about 5 ml, about 10 ml, about 12.5 ml, about 15 ml, about 20 ml, or any value or range between any two of these values.

In various embodiments, the hollow lumen 107 may include a plurality of plungers disposed therein. For example, in the present embodiment, the hollow lumen 107 may have a first plunger 120 and a second plunger 135. However, those skilled in the art will recognize that more than two plungers may be used without departing from the scope of this disclosure. In various embodiments, the first plunger 120 may form a seal against the interior of the syringe body 105 by means of a first seal 125. In some embodiments, the first seal 125 may be a separate component from the first plunger 120, such as, for example, an added O-ring and/or the like. In these embodiments, the first seal 125 may be fixedly attached to the first plunger 120 by any means of attachment, including attachment apparatuses, adhesives, and/or the like, or the first seal may be removably attached to the first plunger. In other embodiments, the first seal 125 may be fabricated as a portion of the first plunger 120. Similarly, in various embodiments, the second plunger 135 may form a seal against the interior of the syringe body 105 by means of a second seal 140. In some embodiments, the second seal 140 may be a separate component from the second plunger 135, such as, for example, an added O-ring and/or the like. In these embodiments, the second seal 140 may be fixedly attached to the second plunger 135 by any means of attachment, including attachment apparatuses, adhesives, and/or the like, or the second seal may be removably attached to the second plunger. In other embodiments, the second seal 140 may be fabricated as a portion of the second plunger 135. The first plunger 120, the second plunger 135, the first seal 125, and the second seal 140 may each be made of any material now known or later developed that is known by those skilled in the art for use in plungers and/or seals. Specific examples may include polymers, rubber, and/or the like.

In various embodiments, a first compartment 160 may be formed between the first plunger 120 and the distal end 102 of the syringe body 105. The first compartment 160 may be configured to contain a fluid therein. In particular embodiments, the fluid may include a contrast medium. In various embodiments, a second compartment 165 may be formed between the second plunger 135 and the first plunger 120. The second compartment 165 may also be configured to contain a fluid therein. In particular embodiments, the fluid may include a flushing fluid. One such specific example of a flushing fluid may be saline. The volume of the first compartment 160 may be determined by the distance between the first plunger 120 and the distal end 102 of the syringe body 105, as well as the circumference of the syringe body. The volume of the second compartment 165 may be determined by the distance between the first plunger 120 and the second plunger 135, as well as the circumference of the syringe body 105.

In various embodiments, the first plunger 120 and the second plunger 135 may be joined together by means of a connection piece 130. The connection piece 130 may be constructed so that when force is applied on the second plunger 135, some of the force is transferred to the first plunger 120 to effect movement of the first plunger along with the second plunger. In some embodiments, movement may be bidirectional, i.e., the force can be directed proximally or distally to move the first plunger 120 and the second plunger 135 in either a proximal or distal direction within the syringe. In these embodiments, the connection piece 130 may be constructed of a rigid material that does not bend or collapse when pressure is applied to it. The connection piece 130 may further be constructed of any material that does not impact any fluid that may come into contact with it. In other embodiments, movement may be unidirectional, i.e., a force that pushes the second plunger 135 in a distal direction may not be transferred to the first plunger 120 so that the first plunger stays in place, but when the opposite force in a proximal direction is placed on the second plunger, the force is transferred to the first plunger, causing it to move as well. In some embodiments, as shown in FIG. 1A, this unidirectional movement may be possible by using a connection piece 130′ that is constructed of a collapsible material. Specific examples of collapsible materials may include filaments, monofilaments, fibers, polymers, and the like. In some embodiments, the connection piece 130 (or 130′) may include one or more magnets so that the force on the second plunger 135 causes a force on the first plunger 120 due to magnetic attraction. In some embodiments, the connection piece 130 (or 130′) may include a releasable pin or similar locking device that can lock or unlock the connection piece to effectuate a desired movement of the plungers 120, 135 as described herein. As in the other constructions, the connection piece 130 (or 130′) may further be constructed of any material that does not impact any fluid that may come into contact with it.

In various embodiments, particularly embodiments in which the connection piece is a collapsible material 130′, the first plunger 120 may be moved towards the distal end 102 of the syringe body 105 under force from the fluid located within the second chamber 165. For example, due to the actions of the second seal 140 and the first seal 125, the fluid contained within the second compartment 165 does not leak or compress, but rather acts as a hydraulic lock, thereby transferring force from the second plunger 135 to the first plunger 120. In this manner, the fluid located in the first compartment 160 may be pushed distally by the first plunger 120, where, in some embodiments, it may be forced out the syringe tip 110.

In various embodiments, the second plunger 135 may be connected to a piston 145 that may at least partially extend out of an opening in the proximal end 101 of the syringe body 105. The second plunger 135 may be attached to the piston 145 by any means of attachment, including, but not limited to, any number of clips, fasteners, hooks, adhesives, and/or the like. In some embodiments, the second plunger 135 may be molded as a portion of the piston 145. In some embodiments, the piston 145 may have a thumb piece 150 proximally attached thereto. The thumb piece 150 may generally provide a stable surface to allow the user of the syringe 100 to push and/or pull the piston 145, and correspondingly the second plunger 135 and/or the first plunger 120. The thumb piece 150 depicted herein is a generally flat surface; however, those skilled in the art will recognize that the shape and size of the thumb piece is not limited by this disclosure, and may include any number of rings, openings, contoured surfaces, and/or the like without departing from the scope of the present disclosure. Persons skilled in the art will also note that the term ‘thumb piece’ is not to be limiting; the user may use any object to manipulate the thumb piece 150 as described herein.

In various embodiments, the interior surface of the syringe body 105 may include a plurality of recesses 155 disposed therein, causing a void in portions of the interior surface at the location of each recess. In some embodiments, the plurality of recesses 155 may be disposed about the inner wall of the syringe body 105 near the distal end 102. The shape and size of the recesses 155 is not limited by this disclosure, and may generally be any shape and/or size that will break the seal between the syringe body 105 and the first seal 125 of the first plunger 120. In some embodiments, the recesses 155 may be scalloped. In other embodiments, the recesses 155 may be crenelated. The recesses 155 may be located at any position on the inside wall of the syringe body 105, and may be positioned so as to correspond to an amount of fluid that is desired in the first compartment 160 and/or the second compartment 165. However, the recesses 155 cannot be located so far distal in the syringe body that the first seal 125 does not contact it, as the fluid in the second compartment 165 would not be released. In some embodiments, the recesses 155 may be positioned at a tapered transition point from the cylindrical syringe body 105 to the tip 110.

In various embodiments, one or more finger guards 115 may be positioned at a location that is generally located at or near the proximal end 101 of the syringe body 105. In some embodiments, the finger guards 115 may generally be located on an outside surface of the syringe body 105 and may generally extend from the outside surface of the syringe body. In some embodiments, the finger guards 115 may act to provide stability to the syringe 100 during operation. In some embodiments, a user may use the finger guards 115 to prevent movement of the syringe 100 during operation. In some embodiments, the user may use the finger guards 115 to prevent the syringe 100 from slipping out of the user's hand. In some embodiments, the user may use the finger guards 115 to protect the user's fingers. In some embodiments, the finger guards 115 may act as a stopping device to prevent the piston 145 from moving further distally inside the syringe body 105. The shape and size of the finger guards 115 are not limited by this disclosure, and may be any shape and/or size known in the art. Specific examples of shapes may be ring shaped, wedge shaped, T-shaped, curved, curved with finger indentations, and/or the like.

FIG. 2A depicts a side view of an alternative syringe, generally designated 200, according to an embodiment. Similar to the syringe 100 disclosed with respect to FIGS. 1A and 1B above, the syringe 200 may include a syringe body 205 having a proximal end 201 and a distal end 202. The syringe body 205 may have a first plunger 220 and a second plunger 235 disposed within it. The first plunger 220, the second plunger 235, and a tip 210 may define a first compartment 260 and a second compartment 265 therein for storing two different types of fluid, as previously described herein. The first plunger 220 and the second plunger 235 may be moved within the syringe body 205 by applying a force to the thumb piece 250 portion of a piston 245, as previously described herein. In some embodiments, movement of the first plunger 220 may be aided by the connection piece 230, as described herein. In alternate embodiments, movement of the first plunger 220 may be aided by transfer of force on the second plunger 235 to the first plunger 220 via a fluid located in the second compartment 265, as also described herein.

In various embodiments, the alternative syringe of FIG. 2A may differ from the syringe of FIGS. 1A and 1B by including, among other things, a transfer tube 270, a valve 275, and one or more outlet ports 280. In some embodiments, the recesses 255 may not be present. In some embodiments, the functions of these additional elements, as described herein, may allow for the syringe 200 to provide a “keep vein open” (KVO) function. The KVO function may be used during a long term injection procedure to ensure that access to a vein remains available for fluid injection and does not collapse when fluid is not being administered. In some embodiments, the functions of these additional elements may allow for the syringe 200 to provide functionality for delivering the fluid of the second compartment 265 before delivering the fluid of the first compartment 260 and vice versa. In some embodiments, the functions of these additional elements may allow for the syringe 200 to provide functionality for mixing at least a portion of the contents in the first compartment 260 with at least a portion of the contents in the second compartment 265 during delivery to a patient. In some embodiments, the functions of these additional elements may allow for the syringe 200 to be in an “off” state, thus preventing the contents from either compartment 260, 265 from escaping, such as to prevent leakage when the syringe is not in use.

In various embodiments, the transfer tube 270 may be in fluid connection with the contents of the second compartment 265 within the syringe body 205. Thus, in some embodiments, the syringe body 205 may contain an opening and/or a bore therein for attachment of the transfer tube 270 to allow for a fluid connection thereof. The construction of the transfer tube 270 is not limited by this disclosure and may be of any shape, size, and/or composition. In some embodiments, the transfer tube 270 may be generally hollow to allow transfer of a fluid therethrough, and may generally be made of a substance that does not impact the fluid flowing therethrough.

In alternative embodiments, such as the embodiment shown in FIG. 2B, the transfer tube 270′ may be in fluid connection with the contents of both the first compartment 260 and the second compartment 265, depending on the positioning of the plungers 220, 235. In some embodiments, the transfer tube 270′ may act as an alternative to the recesses 255 (FIG. 2A). Thus, the transfer tube 270′ may allow for transfer of fluid to/from the first compartment 260 only when first compartment 260 is exposed to the transfer tube and the valve 275 is particularly positioned, as described in greater detail herein. Furthermore, the transfer tube 270′ may allow for transfer of fluid to/from the second compartment 265 only when the second compartment 265 is exposed to the transfer tube and the valve 275 is particularly positioned, as described herein. In addition, because the recesses are not present in this embodiment, the first plunger 220 may continue to form a seal with the inner wall of the syringe body 205, even as it is being forced in a distal direction, so fluids in the second compartment 265 will only be able to exit the syringe 200 via the transfer tube 270′ when the valve 275 is particularly positioned, as described herein.

As shown in either embodiment of FIGS. 2A and 2B, the transfer tube 270 may terminate in the valve 275. In some embodiments, the valve 275 may be in fluid connection with the transfer tube 270, the tip 210 and the outlet port 280. In various embodiments, the valve 275 may be configured to be positioned in one of a plurality of states, in which it is open to any or none of the elements in which it is fluidly connected, as shown in FIG. 3. A first state, as depicted in position (a), allows contents to flow from both the tip 210 and the transfer tube 270 to the outlet port 280. A second state, as depicted in position (b), only allows contents from the transfer tube 270 to be dispensed into the outlet port 280, as it blocks the contents in the tip 210. A third state, as depicted in position (c), only allows contents from the tip 210 to be dispensed into the outlet port 280, as it blocks the contents in the transfer tube 270. A fourth state, as depicted in position (d), does not allow the contents of either location to be dispensed into the outlet port 280 because the valve 275 is closed off to both the transfer tube 270 and the tip 210. Those skilled in the art will recognize that contents may be drawn into the syringe 200 in a similar manner, as described in greater detail herein.

In various embodiments, the outlet port 280 may be configured to receive the contents from the first chamber 260, the second chamber 265, both chambers, or neither chamber depending on the orientation of the valve 275 and/or the location of the transfer tube 270 (or 270′). The outlet port 280 may further be configured to output any contents received to a patient. In some embodiments, the outlet port 280 may be configured to securely attach to additional elements, such as tubes, needles, nozzles, valves, catheters, and the like to aid in delivery of the contents to the patient.

FIG. 4 depicts a side view of another alternative syringe system according to an embodiment. The syringe system 400 may include a syringe body 405 having a first chamber 410 and a second chamber 420. Unlike in other embodiments depicted herein, the first chamber 410 and second chamber 420 may not be in line with each other. Rather, the chambers 410, 420 may be positioned adjacent to each other, such as, for example, substantially parallel to each other. A distal end of each chamber 410, 420 may be fluidly connected to an output 445. In some embodiments, the output 445 may be configured to transmit the contents of the first chamber 410 and/or the second chamber 420 to a subject. In some embodiments, the output 445 may be configured to attach to other devices, such as, for example, tubes, nozzles, needles, valves, catheters, and the like, as described in greater detail herein.

In various embodiments, the first chamber 410 may have a first plunger 415 and a cavity for housing and dispensing a first fluid therein. Similarly, the second chamber 420 may have a second plunger 425 and a cavity for housing and dispensing a second fluid therein. In some embodiments, a diameter of the first chamber 410 may be smaller than a diameter of the second chamber. The second plunger 425 may be actuated by receiving a force in a distal direction, as described in greater detail herein. Because the diameter of the second chamber 420 is larger than the diameter of the first chamber 410, the force on the second plunger 425 that causes fluid to move out of the second chamber and into the output 445 may cause a Venturi effect on the fluid in the first chamber, causing it to be drawn out into the output with the fluid from the second chamber. In some embodiments, a constant force spring 440 may be configured to ensure that the force applied to the second plunger 425 is fluid and uniform to effectuate a smooth delivery of the contents of the chambers 410, 420 to a subject.

In various embodiments, the syringe system 400 may include a stop 430. In some embodiments, the stop 430 may be configured to block movement of the first plunger 415 after movement over a certain distance has occurred. The position of the stop 430 may be adjustable by actuating a stop adjustment screw 435. By changing the positioning of the stop 430, a user can dictate the amount of distance that the first plunger 415 can be moved before being stopped by the stop. In an illustrative example, a force may be applied to the second plunger 425 to cause the first plunger 415 and the second plunger to move distally in their respective chambers 410, 420, as described herein. Once the first plunger 415 reaches the stop 430, additional distal movement of the first plunger may cease, thereby preventing additional fluid from exiting the first chamber 410, while additional distal movement of the second plunger 425 may continue until all of the contents of the second chamber 420 have been displaced out of the second chamber.

FIG. 5 depicts a side view of yet another alternative syringe according to an embodiment. Similar to the syringe 100 disclosed with respect to FIGS. 1A and 1B above, the syringe 500 may include a syringe body 505 having a proximal end 501 and a distal end 502. The syringe body 505 may have a first plunger 520 and a second plunger 535 disposed within it, however, unlike the embodiments of FIGS. 1A and 1B, the second plunger may be located inside the first plunger, as will be described in greater detail herein. The first plunger 520 and the second plunger 535 may be moved within the syringe body 505 by applying a force to the thumb piece 550 portion of a piston 545, as previously described herein.

In various embodiments, the first plunger 520 may form a seal against the interior of the syringe body 505 by means of the first seal 525, as previously described herein. A first chamber 560 may be defined by the first plunger 520 and the tip 510, as previously described herein. The first chamber 560 may further be configured to house a fluid therein, where the fluid is forced out of the tip 510 upon a force applied to the thumb piece 550, as previously described herein.

In various embodiments, the first plunger 520 may be substantially hollow and configured to house at least the second plunger 535 and a check valve 523, such as a one-way check valve or the like, therein. In some embodiments, the second plunger 535 may form a seal against the interior of the first plunger 520 by means of the second seal 540. Accordingly, the second chamber 565 may be defined by the second plunger 535 and the remainder of the hollow space within the first plunger 520. Furthermore, the second plunger 535 may be configured to slidably move within the first plunger 520 independently of movement of the first plunger within the syringe body 505. In some embodiments, the check valve 523 may be configured to activate, thereby plugging an opening in a distal portion 521 of the first plunger 520. In some embodiments, the check valve 523 may further be configured to release, thereby allowing the contents of the second chamber 565 to be released distally into the first chamber 560 and/or the tip 510. In some embodiments, a third seal 524 positioned distally on the first plunger 520 may allow a distal portion of the first plunger to seal against a distal portion of the syringe body 505 so that the fluid from the second compartment 565 does not flow back into the syringe body when it is ejected, as described in greater detail herein.

In various embodiments, the second plunger 535 may be removably attached to at least a portion of the piston 545. In some embodiments, the second plunger 535 may include a proximally located attachment member 537 affixed thereto. The attachment member 537 of the second plunger 535 may generally be configured to removably attach to an attachment member 548 of the piston 545.

In various embodiments, the piston 545 may include at least an inner piston 547 and an outer sleeve 546. In some embodiments, the inner piston 547 may extend from the thumb piece 550 to the attachment member 548. In various embodiments, the inner piston 547 may have a shape and size that, when the inner piston is actuated, it can move independently of the outer sleeve 546, cause the attachment member 548 to attach to the attachment member 537 of the second plunger 535 without substantially contacting the first plunger 520, and force the second plunger to move within the first plunger without causing movement of the first plunger within the syringe body 505. In some embodiments, the outer sleeve 546 can be actuated independently of the inner piston 547 and can further move independently of the inner piston. In some embodiments, the outer sleeve 546 may have a shape and/or size that are configured to allow the outer sleeve to contact at least a portion of the proximal end of the first plunger 520 without substantially contacting the second plunger 535. In some embodiments, a force may be applied to the outer sleeve 546 to cause the outer sleeve to force the first plunger 520 to move within the syringe body 505, as described in greater detail herein. In some embodiments, the inner piston 547 and the outer sleeve 546 may be locked together with a locking mechanism (not shown) so that, when a force is applied to the thumb piece 550, the entire piston 545 moves as one.

In various embodiments, the syringe body 505 may further include one or more valve actuators 511 positioned at a location within the inside surface of the syringe body. In the present example, the valve actuators 511 are located near the tip 510; however, those skilled in the art will recognize that the valve actuators may be positioned at any location without departing from the scope of the present disclosure. In some embodiments, the valve actuators 511 may be configured to release the one-way check valve 523 upon contact between the valve actuators and the check valve. In some embodiments, the valve actuators 511 may be configured to activate the check valve 523 upon removal of contact between the valve actuators and the check valve.

FIGS. 6A-6D depict movement of the various components of the syringe 100 depicted in FIGS. 1A and 1B according to an embodiment. More particularly, FIG. 6A depicts an initial state of the syringe 100 when it is loaded with a first fluid in the first compartment 160 and a second fluid in the second compartment 165. As previously described herein, a user may apply a force on the thumb piece 150 to force the piston 145 in a distal direction into the syringe body 105. As a result, the piston 145 may mechanically force the second plunger 135 in the distal direction towards the syringe tip 110. As previously described herein, due to the actions of the second seal 140 and the first seal 125, the fluid located in the second compartment 165 may not leak or compress, but rather may act as a hydraulic lock, thereby transferring the force from the second plunger 135 to the first plunger 120, causing the first plunger to also move in the distal direction towards the syringe tip 110, as shown in FIG. 6B. Accordingly, the fluid contained in the first compartment 160 may be forced out of the syringe tip 110.

In various embodiments, the fluid located in the first compartment 160 may be pushed out through the tip 110 by the first plunger 120 until the mechanical force on the piston 145 (via the second plunger 135 and the force from the fluid in the second compartment 165) drives the first plunger to the recesses 155. In some embodiments, at the recesses 155, the first seal 125 may no longer act as a fluid seal against the inner surface of the syringe body 105. Because the hydraulic seal of the first plunger 120 against the interior of the syringe body 105 is broken in this state, the fluid located in the second compartment 165 may flow around the recesses 155, through the remaining space in the first compartment 160, and out the tip 110. FIG. 6C depicts a cross sectional view of the syringe 100 as the first seal 125 contacts the recesses 155 according to various embodiments. In some embodiments, the first seal 125 may contact one or more cops 156, but does not fill one or more crenels 157 of the recesses 155. Thus, in some embodiments, the fluid from the second compartment 165 (FIG. 6B) may flow through the crenels 157 and out the tip 110 (FIG. 6B).

FIG. 6D depicts the result of the completed delivery by the syringe 100 of the fluid from both the first compartment 160 and the second compartment 165 according to various embodiments. In some embodiments, the thumb piece 150 may have been pushed completely to the end of the finger guards 115. As a result, the piston 145 may have moved the length of its travel, and the second plunger 135 may be extended to its most distal position. In some embodiments, the second compartment 165 may have been compressed to a minimum volume, and the fluid previously contained therein may have been delivered around the first plunger 120 and through the first compartment 160, as disclosed in greater detail herein. Although FIG. 6D illustrates a residual volume in the second compartment 165 due to the illustrated geometry of the first plunger 120 and the second plunger 135, it may be appreciated that the two plungers may be fabricated so that the distal surface of the second plunger and the proximal surface of the first plunger allow for a minimal to zero volume when the second plunger is completely extended distally. FIG. 6D also illustrates that the connection piece 130 may be in an un-tensioned state at the end of fluid delivery. As previously described herein, the connection piece 130 may be designed to impart a force on the first plunger 120 when the second plunger 135 is withdrawn towards the proximal end 101 of the syringe body 105, and may not transfer a force to the first plunger while the second plunger is pushed toward the distal end of the syringe.

In various embodiments, the syringe 100 may be filled by operating in a reverse order of delivery. Thus, in some embodiments, an empty syringe 100 may begin with both the first plunger 120 and the second plunger 135 at the distal end 102 of the syringe body 105. In some embodiments, the second fluid may be introduced first into the second compartment 165 from the tip 110 when a user moves the thumb piece 150 in a proximal motion away from the finger guard 115. The proximal movement of the thumb piece 150 may cause the piston 145 and the mechanically coupled second plunger 135 to also move proximally. In some embodiments, the second plunger 135 may be withdrawn proximally into the syringe body 105, thereby taking up the slack in the connection piece 130. Once the second plunger 135 has moved sufficiently in a proximal direction into the syringe body 105 (see FIG. 6B), the connection piece 130 may be pulled taut and further proximal motion on the piston 145 may be transferred to the first plunger 120. Once the first seal 125 is pulled into the syringe body 105 proximal to the recesses 155, the second compartment 165 may be sealed, and no additional fluid may be introduced into the second compartment. At this point, the thumb piece 150 may be further retracted proximally. Once the first seal 125 of the first plunger 120 is engaged against the interior surface of the syringe body 105, a first fluid introduced through the tip 110 may be delivered to the first compartment 160.

FIGS. 7A-7C depict movement of the various components of the syringe 200 depicted in FIG. 2A according to an embodiment. As described in greater detail herein, pressure on the thumb piece 250 may be transferred through the piston 245 to the second plunger 235. Barring any fluid path from the second compartment 265, a hydraulic lock will force the first plunger 220 in the distal direction, as described in greater detail herein. Thus, if the valve 275 is in either the third or fourth states as shown in FIG. 3, no fluid may flow through the transfer tube 270 from the second compartment and in some embodiments, particularly if the valve 275 is in the third state, fluid from the first compartment 260 will be delivered through the tip 210 and the outlet port 280 in a similar manner as the embodiment shown in FIGS. 1A and 1B. FIG. 7B illustrates the result of the valve 275 in a second state. In some embodiments, when the valve 275 is in either the first or second states (FIG. 3), fluid from the second compartment 265 may travel through the transfer tube 270 as indicated by the directional arrow D and out the outlet port 280. As a result, the hydraulic lock between the second plunger 235 and the first plunger 220 may be released, and the first plunger is no longer driven by the second plunger until they come in physical contact with each other, as shown in FIG. 7C. In some embodiments, because the second plunger 235 can move independently of the first plunger 220, the connection piece 230 may lose tension, as illustrated in FIGS. 7B and 7C.

In various embodiments, it may be appreciated that the syringe 200 may be filled by operating in a reverse order of the delivery, as previously described herein. The valve 275 may be adjusted according to whether it is desired to fill the first compartment 260 or the second compartment 265, and the plungers may be forced in a proximal direction to effect intake of fluid into the respective compartments.

FIGS. 8A-8C depict movement of the various components of the syringe 500 depicted in FIG. 5 according to various embodiments. In some embodiments, the inner piston 547 may be released from the outer sleeve 546 to slide distally, bring the attachment member 548 of the piston in contact with the attachment member 537 of the second plunger 535 and lock the two attachment members together. The inner piston 547 may be locked to the outer sleeve 546 so that they are configured to move in unison and, upon receipt of a force on the thumb piece 550, cause the first plunger 520 to move in a substantially distal direction toward the tip 510. The movement of the first plunger 520 may cause a first fluid contained within the first compartment 560 to be ejected from the tip 510.

In various embodiments, once the first plunger 520 comes into contact with a distal portion of the syringe body 505, it may form a third seal 524 with the distal portion of the syringe body to prevent a second fluid in the second compartment 565 from escaping in a proximal direction around the outside of the first plunger. In some embodiments, the valve actuators 511 may apply a force upon contacting the check valve 523, causing the check valve to actuate. In particular embodiments, the valve actuators 511 may apply the force in a proximal direction, thus forcing the check valve 523 to actuate by moving the check valve proximally into the second compartment 565. By forcing the check valve into the second compartment 565, a passageway may open between the second compartment 565 and the tip 510, thus allowing the second fluid from the second compartment to flow to the tip. In various embodiments, the inner piston 547 may once again be unlocked from the outer sleeve 546 so that it can move independently of the outer sleeve. A force may be applied to the inner piston 547 to cause the second plunger 535 to move in a distal direction within the first plunger 520, thereby forcing the second fluid out of the second compartment 565 and through the tip 510.

In various embodiments, it may be appreciated that the syringe 500 may be filled by operating in a reverse order of the delivery, as previously described herein. The second plunger 535 may be forced in a proximal direction by the inner piston 547, thereby drawing the second fluid into the second compartment 565. Once the second plunger 535 contacts a proximal portion of the first plunger 520, the proximally directed force may draw the first plunger in a proximal direction as well. Removal of the first plunger 520 from the distal portion of the syringe body 505 may cause the valve actuators 511 to allow the check valve 523 to slide distally within the first plunger, thereby sealing the contents of the second compartment 565 therein. Further force upon the first plunger 520 in a proximal direction may allow the first fluid to be drawn into the first compartment 560, as previously described herein.

Still other embodiments of the multiple compartment syringe system may comprise a syringe body comprising a hollow lumen and a distal end, the syringe body being configured to house a plurality of fluids therein; a first plunger positioned in the hollow lumen of the syringe body, forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe; a second plunger positioned proximal to the first plunger in the hollow lumen of the syringe body, forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger; a fluid bypass disposed about the inner wall of the syringe body and the first plunger at or near the distal end of the syringe body, wherein a first fluid can flow through the fluid bypass to the second compartment; and a mechanism for proximally moving the first plunger to a position proximal to the fluid bypass such that the first plunger forms the first seal, the mechanism comprising one of a slidable end cap at the distal end of the syringe body, a push rod configured to push the first plunger in the proximal direction, and a sleeve comprising at least one magnet at or near the distal end of the sleeve and in magnetic communication with at least one magnet or ferromagnetic material in the first plunger.

Certain embodiments of the multiple compartment syringe are illustrated in FIGS. 9A-9B. According to these embodiments, the syringe 900 may comprise a reversibly slidable end cap 940 which selectively controls fluid connection between a first volume compartment 950 and a second volume compartment 955. The syringe comprises cylindrical syringe body 910 having a hollow lumen and end cap 940 comprising a circumferential wall 941 slidably retained in the inner wall of the distal end of syringe body 910 and having syringe tip 942 having a fluid intake/egress passage 945. The syringe tip 942 may further include a conventional connector known in the art, such as, for example a luer connector, to connect the tip to any conventional fluid delivery device, such as a needle, catheter, or tube. The syringe further comprises a distal first plunger 930 and a proximal second plunger 920, wherein second plunger 920 is connected to a thumb piece 965 by piston 960. The area between the second plunger 920 and the first plunger 930 defines the first volume compartment 950 and the area between the first plunger 930 and the end cap 940 defines fluid passage 955′ when first plunger 930 and end cap 940 are in the fully distal position (as illustrated in FIG. 9A) and defines a second volume compartment 955 when first plunger 930 is drawn proximally away from end cap 940 (as illustrated in FIG. 9B). FIG. 9A also illustrates fluid bypass 915 which fluidly connects passage 945 with the first volume compartment 950 via fluid passage 955′ when end cap 940 is in the distal position. Applying a proximal force “b” to thumb piece 965 moves piston 960 and second plunger 920 is a proximal direction which will cause a first fluid, such as a flushing fluid, for example, saline, to flow from a flushing fluid source through passages 945 and 955′ and fluid bypass 915 into the first volume compartment 950. According to certain non-limiting embodiments, the fluid bypass may comprise a plurality disposed about the inner wall of the syringe body at or near the distal end of the syringe, such as, for example, scalloped or crenelated recesses. Once the desired volume of flushing fluid has been drawn into first volume compartment 950, the syringe may be shifted to a second mode to draw in a second fluid, such as a pharmaceutical solution, for example, a medicament, contrast agent or radiopharmaceutical, into second volume compartment 955 (shown in FIG. 9B). Shifting to the second mode is accomplished by applying a proximal force “a” on syringe end cap 940, such as by pushing end cap 940 against a surface. Force “a” causes end cap 940 and circumferential wall 941 to slide in a proximal direction to seal against an edge of the inner wall of syringe body 910, thereby closing and sealing bypass 915. Syringe tip 942 is attached to a source of the second fluid and the second fluid is drawn into volume compartment 955 by applying proximal force “b” to thumb piece 965 which moves piston 960 and second plunger 920 in a proximal direction and also moves first plunger 930 proximally by hydraulic force from a hydraulic lock. Once aspiration of the second fluid is complete and the desired amount of the second fluid has been drawn into second volume compartment 955, the syringe may be used to deliver the second fluid in volume compartment 955 to a patient followed by delivery of the flushing fluid in volume compartment 950 to flush the fluid delivery device and ensure complete delivery of the second fluid. As shown in FIG. 9C, application of distal force “b” to thumb piece 965 forces piston 960 and second plunger 920 in a distal direction which forces first plunger 930 in a distal direction by the hydraulic lock delivering the second fluid through passage 945. Once the distal edge of the first plunger 930 meets the inner surface of end cap 940 and the second fluid has substantially been delivered through passage 945, the first plunger 930 then forces end cap 940 distally to the end of the syringe body (force “a”) thereby unsealing and opening up fluid bypass 915. Continued application of distal force on thumb piece 965 results in delivery of flushing fluid in volume compartment 950 through fluid bypass 915 and fluid passages 955′ and 945. By this method, the various embodiments of this syringe may sequentially aspirate a flushing fluid and pharmaceutical and deliver the pharmaceutical followed by flushing with the flushing fluid.

In another embodiment, illustrated in FIGS. 10A and 10B, syringe 1000 may allow sequential aspiration of a flushing fluid and a pharmaceutical and delivery of the pharmaceutical followed by flushing with the flushing fluid. According to this embodiment, the syringe 1000 may comprise a push rod 1080 which selectively controls fluid connection between a first volume compartment 1050 and a second volume compartment 1055. The syringe comprises cylindrical syringe body 1010 having a hollow lumen and a T-connector 1070 comprising push rod 1080 at the distal end of syringe body 1010 and having syringe tip 1042 having a fluid intake/egress passage 1045. The syringe tip 1042 may further include a conventional connector known in the art, such as, for example a luer connector, to connect the tip 1042 to any conventional fluid delivery device, such as a needle, catheter, or tube, after loading the syringe. The syringe further comprises a distal first plunger 1030 and a proximal second plunger 1020, wherein second plunger 1020 is connected to a thumb piece 1065 by piston 1060. The area between the second plunger 1020 and the first plunger 1030 defines the first volume compartment 1050 and the area between the first plunger 1030 and the distal end of the syringe defines fluid passage 1055′ when first plunger 1030 is in the fully distal position (as illustrated in FIG. 10A) and defines a second volume compartment 1055 when first plunger 1030 is drawn proximally away from the distal end of the syringe (as illustrated in FIG. 10B). T-connector 1070 fluidly connects fluid passage 1045 with fluid inlet 1075. FIG. 10A also illustrates fluid bypass 1015 which fluidly connects passage 1045 with the first volume compartment 1050 via fluid passage 1055′ when first plunger 1030 is in the distal position. Applying a proximal force to thumb piece 1065 moves piston 1060 and second plunger 1020 in a proximal direction which causes a first fluid, such as a flushing fluid, for example, saline, to flow from a flushing fluid source through passages 1075, 1045 and 1055′ and fluid bypass 1015 into the first volume compartment 1050. Once the desired volume of flushing fluid has been drawn into first volume compartment 1050, the syringe may be shifted to a second mode to draw in a second fluid, such as a pharmaceutical solution, for example, a medicament, contrast agent or radiopharmaceutical, into second volume compartment 1055 (shown in FIG. 10B). Shifting to the second mode is accomplished by applying a proximal force on push rod 1080. Proximal force on push rod 1080 forces first plunger 1030 in a proximal direction until sealing means 1035 contact and seal against an edge of the inner wall of syringe body 1010, thereby sealing volume compartment 1050 from bypass 1015. Syringe tip 1042 is attached to a source of the second fluid, for example, via passage 1075 in T-connector 1070 and the second fluid is drawn into volume compartment 1055 by applying proximal force to thumb piece 1065 which moves piston 1060 and second plunger 1020 in a proximal direction and also moves first plunger 1030 proximally by a hydraulic lock. In addition, the second fluid may be drawn into volume compartment 1050 upon pushing first plunger 1030 with push rod 1080. Push rod 1080 is sealed with the inner walls of T-connector 1070 by sealing means 1072 to prevent fluid leakage therethrough. Once aspiration of the second fluid is complete and the desired amount of the second fluid has been drawn into second volume compartment 1055, the syringe may be used to deliver the second fluid in volume compartment 1055 to a patient followed by delivery of the flushing fluid in volume compartment 1050 to flush the fluid delivery device and ensure complete delivery of the second fluid. In one embodiment, fluid delivery may be through a fluid delivery device attached to fluid passage 1075 of T-connector 1070. In another embodiment fluid delivery may be though a fluid delivery device attached to fluid passage 1045 after removal of T-connector 1070. Sequential delivery of the second fluid and flushing fluid may occur in a manner similar to the syringe of FIG. 9C, described herein. That is, application of a distal force on thumb piece 1065 pushes piston 1060 and the second plunger 1020 in a distal direction which forces the first plunger 1030 in a distal direction, thus delivering the second fluid through passage 1042. Once the plunger sealing means 1035 reach the fluid bypass 1015, generally upon delivery of substantially all of the second fluid, the volume compartment 1050 is fluidly connected to fluid bypass 1015 and the first flush fluid may pass through fluid bypass 1015 and passages 1055′ and 1045 for delivery to a patient with concurrent flushing of the second fluid from the syringe and fluid delivery device.

Another embodiment of the multi-compartment syringe may comprise a syringe having an arrangement of magnets to control selective aspiration and infusion of a first and second fluid. As illustrated in FIGS. 11A and 11B, syringe 1100 may allow sequential aspiration of a flushing fluid and a pharmaceutical and delivery of the pharmaceutical followed by flushing with the flushing fluid. According to this embodiment, the syringe 1100 which selectively controls fluid connection between a first volume compartment 1150 and a second volume compartment 1155. The syringe comprises cylindrical syringe body 1110 having a hollow lumen and sleeve 1170 circumferentially surrounding syringe body 1110 and comprising at least one magnet 1185 in magnetic communication with one or more magnets or ferromagnetic materials 1180 in a distal first plunger 1130 and a proximal second plunger 1120 and having syringe tip 1142 having a fluid intake/egress passage 1145. The syringe tip 1142 may further include a conventional connector known in the art, such as, for example a luer connector, to connect the tip to any conventional fluid delivery device, such as a needle, catheter, or tube, after loading the syringe. The second plunger 1120 may be connected to a thumb piece 1165 by piston 1160. The area between the second plunger 1120 and the first plunger 1130 defines the first volume compartment 1150 and the area between the first plunger 1130 and the distal end of the syringe defines fluid passage 1155′ when first plunger 1130 is in the fully distal position (as illustrated in FIG. 11A) and defines a second volume compartment 1155 when first plunger 1130 is drawn proximally away from the distal end of the syringe (as illustrated in FIG. 11B). Sleeve 1170 surrounds the outer body of syringe 1110 and comprises one or more magnets 1185 and/or 1185′ in magnetic communication with one or more magnets or ferromagnetic material 1180 in one or both of the first plunger 1130 and second plunger 1120. FIG. 11A also illustrates fluid bypass 1115 which fluidly connects passage 1145 with the first volume compartment 1150 via fluid passage 1155′ when first plunger 1130 is in the distal position. Applying a proximal force to thumb piece 1165 moves piston 1160 and second plunger 1120 is a proximal direction which causes a first fluid, such as a flushing fluid, for example, saline, to flow from a flushing fluid source through passages 1145 and 1155′ and fluid bypass 1115 into the first volume compartment 1150. Once the desired volume of flushing fluid has been drawn into first volume compartment 1150, the syringe may be shifted to a second mode to draw in a second fluid, such as a pharmaceutical solution, for example, a medicament, contrast agent or radiopharmaceutical, into second volume compartment 1155 (shown in FIG. 11B). Shifting to the second mode may be accomplished by sliding sleeve 1170 in a proximal direction, for example by the user manually drawing sleeve 1170 in a proximal direction or by a proximal force on proximal magnets 1185′ from magnets 1180 in second plunger 1120 as described herein. Distal magnets 1185 in sleeve 1170 are in magnetic communication with distal magnets or ferromagnetic material 1180 in first plunger 1130 and proximal movement of sleeve 1170 also moves first plunger 1130 in a proximal direction until sealing means 1135 contact and seal against an edge of the inner wall of syringe body 1110, thereby sealing volume compartment 1150 from bypass 1115. In certain embodiments, the proximal magnets 1185′ in sleeve 1170 may be in magnetic communication with the magnets or ferromagnetic material 1180 in the second plunger 1130 and moving sleeve 1170 in a proximal direction may be affected as second plunger 1130 is drawn in a proximal direction. Syringe tip 1142 is then attached to a source of the second fluid and the second fluid is drawn into volume compartment 1155 by applying proximal force to thumb piece 1165 which moves piston 1160 and second plunger 1120 in a proximal direction and also moves first plunger 1130 proximally by the hydraulic lock. According to another embodiment, the volume of the first fluid in the volume compartment 1150 may be determined by the relative distance between distal magnets 1185 and proximal magnets 1185′ on sleeve 1170. According to this embodiment, the first plunger 1130 is in the fully distal position (as shown in FIG. 11A) and the second plunger 1120 is also in the fully distal position in contact with the first plunger. As the thumb piece 1165 is drawn proximally, first plunger 1120 is drawn in a proximal direction with volume compartment 1150 being filled with the first fluid. When the magnets or ferromagnetic material 1180 in the second plunger 1120 reach the position of proximal magnets 1185′ of sleeve 1170, a magnetic attraction is formed and further proximal withdrawal of the second plunger 1120 also causes sleeve 1170 to be withdrawn in a proximal direction, which causes the first plunger 1130 to move proximally past fluid bypass 1115 and thereby draw up the second fluid into volume chamber 1155 (as shown in FIG. 11B). In a further embodiment the volume of the first fluid drawn into syringe 1100 relative to the volume of the second fluid may be controlled by changing the distance between proximal magnets 1185′ and distal magnets 1185. For example, according to one embodiment sleeve 1170 may comprise an adjustable means for changing the distance between magnets 1185 and 1185′, such as having a threaded attachment between a distal section and a proximal section of sleeve 1170 where the threaded attachment can be turned in a clockwise or counter-clockwise direction to lengthen or shorten the distance between magnets 1185 and 1185′, thereby making the volume of volume compartment 1150 larger or smaller when the first and second plunger magnets or ferromagnetic materials 1180 are in communication with sleeve magnets 1185 and 1185′, respectively. Once aspiration of the second fluid is complete and the desired amount of the second fluid has been drawn into second volume compartment 1155, the syringe may be used to deliver the second fluid in volume compartment 1155 to a patient followed by delivery of the flushing fluid in volume compartment 1150 to flush the fluid delivery device and ensure complete delivery of the second fluid. Fluid delivery may be though a fluid delivery device attached to fluid passage 1145. Sequential delivery of the second fluid and flushing fluid may occur in a manner similar to the syringe of FIG. 9C, described herein. That is, application of a distal force on thumb piece 1165 pushes piston 1160 and the second plunger 1120 in a distal direction which forces the first plunger 1130 in a distal direction using a hydraulic lock and/or the magnetic connection between the first and second plungers, thus delivering the second fluid through passage 1145. Once the plunger sealing means 1135 reach the fluid bypass 1115, generally upon delivery of substantially all of the second fluid, the volume compartment 1150 is fluidly connected to fluid bypass 1115 and the first flush fluid may pass through fluid bypass 1115 and passages 1155′ and 1145 for delivery to a patient with concurrent flushing of the second fluid from the syringe and fluid delivery device. It will be understood in those embodiments comprising magnets and ferromagnetic material, interchanging the relative positions of the magnets and ferromagnetic material is within the scope of the present disclosure.

Although various embodiments have been described in detail for the purpose of illustration, it is to be understood that such detail is solely for that purpose and that the disclosure is not limited to the disclosed embodiments, but, on the contrary, is intended to cover modifications and equivalent arrangements. For example, it is to be understood that this disclosure contemplates that, to the extent possible, one or more features of any embodiment can be combined with one or more features of any other embodiment. 

What is claimed is:
 1. A syringe system comprising: a syringe body comprising a hollow lumen and a distal end, the syringe body being configured to house a plurality of fluids therein; a first plunger positioned in the hollow lumen of the syringe body and reciprocally movable within the syringe body to fill the syringe body with movement toward a proximal end of the syringe body and empty the syringe body with movement toward the distal end of the syringe body, the first plunger forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe body; a second plunger positioned proximal to the first plunger in the hollow lumen of the syringe body and reciprocally movable within the syringe body to fill the syringe body with movement toward the proximal end of the syringe body and empty the syringe body with movement toward the distal end of the syringe body, the second plunger forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger; a fluid bypass disposed about the inner wall of the syringe body and the first plunger at or near the distal end of the syringe body, wherein a first fluid can flow through the fluid bypass to the second compartment; and a mechanism for proximally moving the first plunger to a position proximal to the fluid bypass such that the first plunger forms the first seal, the mechanism comprising one of a slidable end cap at the distal end of the syringe body, and a sleeve comprising at least one magnet at or near the distal end of the sleeve and in magnetic communication with at least one magnet or ferromagnetic material in the first plunger.
 2. The syringe system of claim 1, wherein the mechanism comprises a slidable end cap having a circumferential wall comprising the inner wall of the distal end of the syringe body.
 3. The syringe system of claim 2, wherein applying a proximal force to the slidable end cap causes the end cap to slide in a proximal direction and fluidly seal the fluid bypass.
 4. The syringe system of claim 1, wherein the mechanism comprises the sleeve comprising the at least one magnet at or near the distal end of the sleeve and in magnetic communication with at least one magnet or ferromagnetic material in the first plunger, wherein sliding the sleeve in a proximal direction slides the first plunger in the proximal direction.
 5. The syringe system of claim 4, wherein the sleeve is configured to slide by applying a proximal force to an outer wall of the sleeve.
 6. The syringe system of claim 4, further comprising at least one proximal magnet at or near a proximal end of the sleeve and adapted to be in magnetic communication with a magnet or ferromagnetic material in the second plunger.
 7. The syringe system of claim 6, wherein when the at least one proximal magnet is in magnetic communication with the magnet or ferromagnetic material in the second plunger, movement of the second plunger in the proximal direction causes the sleeve and the first plunger to move in the proximal direction.
 8. The syringe system of claim 1, further comprising a piston connected to the second plunger, wherein the piston is configured to be activated by a thumb piece.
 9. The syringe system of claim 1, wherein the first compartment comprises a contrast medium therein and the second compartment comprises a flushing fluid therein.
 10. A syringe system comprising: a syringe body comprising a hollow lumen and a distal end, the syringe body being configured to house a plurality of fluids therein; a first plunger positioned in the hollow lumen of the syringe body and reciprocally movable within the syringe body to fill the syringe body with movement toward a proximal end of the syringe body and empty the syringe body with movement toward the distal end of the syringe body, the first plunger forming a first seal with an inner wall of the syringe body, and forming a first compartment between the first plunger and the distal end of the syringe body; a second plunger positioned proximal to the first plunger in the hollow lumen of the syringe body and reciprocally movable within the syringe body to fill the syringe body with movement toward the proximal end of the syringe body and empty the syringe body with movement toward the distal end of the syringe body, the second plunger forming a second seal with the inner wall of the syringe body, and forming a second compartment between the first plunger and the second plunger; a fluid bypass disposed about the inner wall of the syringe body and the first plunger at or near the distal end of the syringe body, wherein a first fluid can flow through the fluid bypass to the second compartment; and a mechanism for proximally moving the first plunger to a position proximal to the fluid bypass such that the first plunger forms the first seal, the mechanism comprising a push rod configured to push the first plunger in a proximal direction, and further comprises a T-connector connected to a distal tip of the syringe body which directs the push rod into the first compartment to connect with the first plunger.
 11. The syringe system of claim 10, wherein the T-connector is fluidly connected to at least one fluid source. 